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Hepatitis E Virus Serology

Alias: HEV, Hep E

Discipline: Virology

Test information: Used in the diagnosis of acute Hepatitis E (HEV) infection. Reactive samples are sent to the reference laboratory for antibody confirmation and RNA detection. HEV IgM is used as part of the Non-Invasive Liver Screen (NILS) for patients with amino alanine transferase (ALT) levels >300 IU/mL. Usually detectable at the onset of symptoms or abnormal liver function. This may be 2 to 9 weeks after exposure. May be undetectable in acute cases and false positives can occur. Strongly positive results are rarely detected 3 months after the onset of symptoms. A negative result does not exclude the possibility of exposure to or infection with HEV.

Availability: Available locally Monday - Friday during routine hours: 08:45 - 17:15.

Turnaround Time: 3 Days

Specimen Type(s)
  • Clotted blood;
Other Acceptable Specimen Type(s)
Specimen Container - Adult
  • Gold Top SST BD;
Specimen Container - Paediatric
  • Plain Top Sarstedt;
  • Hepatitis E Virus RNA;
  • N/A;
Part of a test profile?
Volume (min) of sample to be sent to laboratory
5 - 10mL
Patient Preparation, Sample Handling and Transport
  • Minimum-clotting time 30 minutes.
  • Specimens should be transported to the laboratory as soon as possible.
  • Outside of normal hours samples should be refrigerated (2 °C to 8 °C).
Maximum add on time
Units and Reference Ranges / Interpretation
Results: Negative / Positive
UKAS number
UKAS accredited test?
Confirmations referred daily Monday to Friday to PHE Colindale.

If you have any queries about a test or results interpretation please contact us.

Last updated: 30-05-2023