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Anti-Streptococcal Serology

Alias: ASO (Anti-Streptolysin O), Anti-DNase B ( Anti-Streptodornase B), ASOT

Discipline: Virology

Test information: ASO (Anti-Streptolysin O) and Anti-DNase B ( Anti-Streptodornase B) are tests used to diagnose recent streptococcal infection in post-streptococcal conditions, such as glomerulonephritis and rheumatic fever.

Availability: Referred to Royal Devon and Exeter NHS Foundation Trust: Monday - Friday during routine hours: 08:45 - 17:15.

Turnaround Time: 2 - 16 Days upon receipt at Royal Devon and Exeter NHS Foundation Trust.

Specimen Type(s)
  • Clotted blood;
Other Acceptable Specimen Type(s)
Specimen Container - Adult
  • Gold Top SST BD;
Specimen Container - Paediatric
  • Plain Top Sarstedt;
  • Anti-DNase B;
  • Anti-Streptolysin O;
Part of a test profile?
Volume (min) of sample to be sent to laboratory
4mL Clotted Blood
Patient Preparation, Sample Handling and Transport
  • Minimum-clotting time 30 minutes.
  • Specimens should be transported to the laboratory as soon as possible.
  • Outside of normal hours samples should be refrigerated (2 °C to 8 °C).
Maximum add on time
Units and Reference Ranges / Interpretation

Anti-streptolysin O: Screening titre <1/200 units.

Anti-DNAse B: Screening titre <1/200 units.

Comment: Positives are consistent with recent streptococcal infection and are most likely to be Group A, C, or G streptococci.

UKAS number
UKAS accredited test?

If you have any queries about a test or results interpretation please contact us.

Last updated: 02-06-2023