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T. whipplei PCR

Alias: Whipple's Disease, Tropheryma whipplei

Discipline: Virology

Test information: A chronic multisystemic disease caused by the bacterium Tropheryma whipplei. Detection of T. whippelii by cell-culture is not a practical diagnostic test and routine serological assays are not yet available. Amplification of nucleic acid by PCR remains the preferred detection method for this organism. Please discuss this investigation with a Consultant Microbiologist first.

Availability: Referred to Great Ormond Street Hospital NHS Foundation Trust: Monday - Friday during routine hours: 08:45 - 17:15.

Turnaround Time: 7 Days upon receipt at Great Ormond Street Hospital NHS Foundation Trust

Specimen Type(s)
  • Cerebrospinal fluid;
  • Duodenal / Jejunal aspirates;
  • Tissue Biopsies;
Other Acceptable Specimen Type(s)
Specimen Container - Adult
  • Purple Top BD;
  • Sterile CE-marked Universal Container;
Specimen Container - Paediatric
  • N/A;
  • Tropheryma whipplei DNA;
Part of a test profile?
Volume (min) of sample to be sent to laboratory
EDTA Whole Blood: 2.5 - 5 mL
CSF: 200 uL

Patient Preparation, Sample Handling and Transport
  • Specimens should be transported to the laboratory as soon as possible.
  • Outside of normal hours samples should be refrigerated (2 °C to 8 °C).
Maximum add on time
Units and Reference Ranges / Interpretation
Results: Negative / DNA NOT Detected, Positive / DNA Detected
UKAS number
UKAS accredited test?

If you have any queries about a test or results interpretation please contact us.

Last updated: 08-06-2023