Skip to main content

Cryptococcus Serology

Alias: CRAG, Cryptococcal antigen, Cryptococcus neoformans

Discipline: Virology

Test information: Diagnosis of infection with Cryptococcus neoformans typically associated with immunosuppression.

Availability: Referred to Severn Pathology North Bristol NHS Trust: Monday - Friday during routine hours: 08:45 - 17:15.

Turnaround Time: 3 Days upon receipt at Severn Pathology North Bristol NHS Trust

Specimen Type(s)
  • Cerebrospinal fluid;
  • Clotted blood;
Other Acceptable Specimen Type(s)
Specimen Container - Adult
  • Gold Top SST BD;
  • Sterile CE-marked Universal Container;
Specimen Container - Paediatric
  • Plain Top Sarstedt;
  • Sterile CE-marked Universal Container;
  • Cryptococcal antigen;
Part of a test profile?
Volume (min) of sample to be sent to laboratory
Blood 2.5 - 5mL
CSF Minimum 0.5mL
Patient Preparation, Sample Handling and Transport
  • Minimum-clotting time 30 minutes.
  • Specimens should be transported to the laboratory as soon as possible.
  • Outside of normal hours samples should be refrigerated (2 °C to 8 °C).
  • This test should only be requested when clinical evidence suggests the diagnosis of Cryptococcal disease. Please contact a consultant microbiologist.
  • Please state the following date of onset of symptoms, any relevant clinical details and indicate type of immunosuppression.
Maximum add on time
Units and Reference Ranges / Interpretation
Results: Negative / Positive
(NEAT specimen or titre given).
UKAS number
UKAS accredited test?

If you have any queries about a test or results interpretation please contact us.

Last updated: 06-06-2023