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Beta-D Glucan

Alias: Aspergillus, Aspergillosis, P. jirovecii, Candida, PCP, Beta Glucan

Discipline: Virology

Test information: Used in the diagnosis of invasive fungal infection in immunocompromised patients.

Availability: Referred to Severn Pathology North Bristol NHS Trust: Monday - Friday during routine hours: 08:45 - 17:15.

Turnaround Time: 3 Days upon receipt at Severn Pathology North Bristol NHS Trust

Specimen Type(s)
  • Clotted blood;
Other Acceptable Specimen Type(s)
Specimen Container - Adult
  • Gold Top SST BD;
Specimen Container - Paediatric
  • Plain Top Sarstedt;
  • Beta-D glucan;
Part of a test profile?
Volume (min) of sample to be sent to laboratory
Patient Preparation, Sample Handling and Transport
  • Minimum-clotting time 30 minutes.
  • Specimens should be transported to the laboratory as soon as possible.
  • Outside of normal hours samples should be refrigerated (2 °C to 8 °C).
  • Samples must be referred within 48 hours of specimen collection.
  • Only send after discussion with consultant microbiologist.
Maximum add on time
Units and Reference Ranges / Interpretation

Beta D-glucan antigen test: Negative / Positive.

Units: pg/mL

Comments: The Beta glucan test has a cut off value of 80 pg/mL. Two consecutive positive values enhance the clinical significance.

A repeatedly positive result may support a diagnosis of invasive fungal infection. Results should always be considered in conjunction with other diagnostic procedures, such as microbiologic culture, histological examination of biopsy specimens, host risk factors and radiographic evidence.

A negative result may be helpful to rule out the diagnosis of invasive fungal infection in some situations.

Not all fungi produce Beta glucan and there are other factors that can lead to raised Beta glucan levels.

UKAS number
UKAS accredited test?

If you have any queries about a test or results interpretation please contact us.

Last updated: 02-06-2023