Elastase

Test information: The faecal elastase assay measures human pancreatic elastase in faecal samples as an indication of pancreatic exocrine function. Pancreatic elastase is a proteolytic enzyme synthesised by the pancreas; it is released into the gastrointestinal tract to help break down food, before being excreted in the faeces. Elastase is not degraded by the intestinal tract; the concentration in faeces is 6 times higher than in duodenal juice. The elastase concentration in the faeces is a reflection of pancreatic exocrine function; its ability to synthesise and release exocrine enzymes required for digestion. Measurement of faecal elastase can be used in the diagnosis of pancreatic insufficiency, causes of which include: chronic pancreatitis, cystic fibrosis, diabetes mellitus, cholelithiasis, and pancreatic cancer.

Specimen Type(s)

• Faeces;

Other Acceptable Specimen Type(s)

N/A

Specimen Container - Adult

• Blue Top Container (Fecon);

Specimen Container - Paediatric

• Blue Top Container (Fecon);
• Sterile CE-marked Universal Container;

Analytes

• N/A;

Part of a test profile?

No

Volume (min) of sample to be sent to laboratory

A single random formed stool sample approx. 2 g (cherry-sized).

Patient Preparation, Sample Handling and Transport

To be frozen on arrival in laboratory

Maximum add on time

N/A

Units and Reference Ranges / Interpretation

>200 µg elastase/g faeces Normal function

UKAS number

8869

UKAS accredited test?

Yes

Comments

Very watery samples should be avoided because the dilutional effect of the stool water can lead to a falsely low result. If a low result is found in a watery sample, a repeat sample will be requested by the laboratory. Very hard/dry stool samples cannot be processed.

If you have any queries about a test or results interpretation please contact us.