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Bilirubin (Total)

Alias: N/A

Discipline: Clinical Chemistry

Test information: Bilirubin is formed in the reticulo-endothelial system mainly the spleen, when aged erythrocytes are degraded. Haem from haemoglobin and other haem-containing proteins is converted to bilirubin, bound to plasma albumin and transported to the liver (unconjugated or indirect bilirubin). In the liver, it is conjugated with glucuronic acid for solubilisation (conjugated or direct bilirubin) and transported through the bile duct for elimination via the digestive tract. Increased bilirubin in the circulation gives rise to jaundice.

Specimen Type(s)
  • Blood;
Other Acceptable Specimen Type(s)
Specimen Container - Adult
  • Gold Top SST BD;
Specimen Container - Paediatric
  • Light Green Top Microtainer BD;
  • N/A;
Part of a test profile?
Liver function
Volume (min) of sample to be sent to laboratory
Patient Preparation, Sample Handling and Transport
The blood sample should ideally be protected from bright light before analysis.
Maximum add on time
24 hours
Units and Reference Ranges / Interpretation
RR for Males and Females
0 days to 14 days -  3 to 284 - umol/L
15 days to less than 1 yr - 1 to 12 - umol/L
1 yr to less than 9 yrs - 1 to 7 - umol/L
9ys to less than 12yrs - 1 to 9 - umol/L
12yrs to less than 15yrs - 2 to 12 - umol/L
15yrs to less than 19yrs - 2 to 14 - umol/L
19yrs & above - <21 - umol/L
UKAS number
UKAS accredited test?

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Last updated: 03-05-2024